Briefly explain why erythromycin and atorvastatin when given together the plasma concentration of atorvastatin increase??

Erythromycin is known to inhibit the enzyme CYP3A4, which is responsible for metabolizing atorvastatin in the liver. When erythromycin is given with atorvastatin, it can inhibit the metabolism of atorvastatin, leading to higher plasma concentrations of atorvastatin in the body. This can increase the risk of atorvastatin-related side effects and toxicity.