Give five drugs that can enter bones and give two characteristics of each drug?

1. Bisphosphonates
- Characteristics: Inhibit bone resorption by osteoclasts, reduce fracture risk in osteoporosis

2. Teriparatide
- Characteristics: Stimulates bone formation by osteoblasts, used for treatment of osteoporosis

3. Denosumab
- Characteristics: Inhibits bone resorption by blocking RANKL, used for treatment of osteoporosis and bone metastases

4. Strontium ranelate
- Characteristics: Stimulates bone formation and inhibits bone resorption, used for treatment of osteoporosis

5. Calcitonin
- Characteristics: Inhibits bone resorption by osteoclasts, used for treatment of osteoporosis and Paget's disease of bone

Drug 1: Strontium Ranelate

- Characteristics:
- Acts as a bone substitute, promoting bone formation and reducing bone resorption.
- Increases bone mineral density and reduces fracture risk in osteoporosis.

Drug 2: Bisphosphonates

- Characteristics:
- Inhibit osteoclastic activity, reducing bone resorption.
- Used to treat osteoporosis, Paget's disease, and other metabolic bone diseases.

Drug 3: Teriparatide

- Characteristics:
- Synthetic form of parathyroid hormone, stimulates bone formation.
- Used to treat severe osteoporosis and hypoparathyroidism.

Drug 4: Denosumab

- Characteristics:
- Monoclonal antibody that inhibits the receptor activator of nuclear factor kappa-B ligand (RANKL), reducing osteoclast activity.
- Used to treat osteoporosis, giant cell tumor of bone, and multiple myeloma.

Drug 5: Zoledronic Acid

- Characteristics:
- Bisphosphonate that is highly potent, inhibiting bone resorption.
- Used to treat osteoporosis, bone metastases, and hypercalcemia of malignancy.