White blood cells, also known as leukocytes, play a crucial role in the body's defense against infection. They are produced in the bone marrow and circulate throughout the bloodstream, lymphatic system, and tissues, constantly scanning for signs of infection. When they detect an infection, they trigger a series of responses to eliminate the invading microorganisms and protect the body from harm.
1. Phagocytosis:
- Neutrophils, macrophages, and other phagocytic white blood cells engulf and destroy foreign particles, bacteria, viruses, and dead cells by surrounding them and engulfing them into their cytoplasm.
- The engulfed particles are then broken down and digested by enzymes within the phagocytic cell.
2. Antibody-Mediated Immunity:
- Lymphocytes, especially B cells, produce antibodies that specifically bind to antigens (foreign proteins) on the surface of invading microorganisms.
- The binding of antibodies to antigens marks the microorganisms for destruction by other cells, such as macrophages and neutrophils.
- Antibodies also neutralize toxins produced by bacteria and viruses.
3. Cell-Mediated Immunity:
- Cytotoxic T lymphocytes (CTLs) recognize and kill infected cells.
- CTLs release cytotoxic substances, such as perforins and granzymes, that create pores in the infected cell membrane, causing it to undergo apoptosis (programmed cell death).
- Natural killer (NK) cells also participate in cell-mediated immunity by killing infected or cancerous cells without requiring prior sensitization.
4. Inflammation:
- White blood cells release cytokines and other chemical messengers that trigger inflammation.
- Inflammation involves redness, swelling, heat, and pain, which helps to localize the infection, prevent its spread, and recruit more immune cells to the site of infection.
5. Memory Response:
- Some lymphocytes, called memory cells, retain a memory of past infections.
- Upon re-exposure to the same antigen, memory cells rapidly mount a strong immune response, providing the body with long-term immunity against specific pathogens.
Overall, white blood cells play a vital role in the body's defense against infection by recognizing, engulfing, and destroying foreign microorganisms, producing antibodies, and triggering cellular and inflammatory responses to eliminate the infection and protect the host from harm.