1. Damage: Severe damage to the limb, such as crush injuries, severe burns, or extensive tissue death, may indicate the need for amputation.
2. Decreased circulation: Poor blood flow to the limb, often due to conditions like peripheral artery disease or severe trauma, can lead to tissue death and may necessitate amputation.
3. Disability: If a limb is severely injured or diseased to the point where it significantly impairs function and quality of life, amputation may be considered to improve mobility and overall health.