Anonymous
Jan 18
Steps on formulation of tablets?
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Jan 18
The formulation of tablets involves several steps. Here is a general outline of the process:
1. Pre-formulation: This step involves the selection of active pharmaceutical ingredients (APIs) and excipients, which are the inactive ingredients that help in the formulation and manufacturing of tablets. The compatibility of APIs and excipients is assessed, and their physical and chemical properties are evaluated.
2. Granulation: Granulation is the process of converting the powdered mixture of APIs and excipients into granules. This step improves the flowability, compressibility, and uniformity of the mixture. Granulation can be achieved through various methods such as wet granulation, dry granulation, or direct compression.
3. Blending: The granules are blended to ensure a homogeneous mixture. This step helps in achieving uniform distribution of APIs and excipients throughout the tablet.
4. Lubrication: Lubricants are added to the blended mixture to reduce friction between the tablet formulation and the tablet press. This step prevents sticking of the tablet to the punches and dies during compression.
5. Compression: The blended and lubricated mixture is compressed using a tablet press. The mixture is fed into the machine, and pressure is applied to form tablets of desired shape, size, and hardness.
6. Coating (optional): Tablets can be coated to improve their appearance, taste, and stability. Coating can also provide protection to the tablet from moisture, light, and other environmental factors. Coating can be done using various techniques such as sugar coating, film coating, or enteric coating.
7. Quality control: Throughout the formulation process, quality control tests are performed to ensure the tablets meet the required standards. These tests include weight variation, hardness, friability, disintegration, dissolution, and content uniformity.
8. Packaging: The final step involves packaging the tablets into suitable containers, such as blister packs or bottles, for distribution and storage.
It is important to note that the specific steps and techniques may vary depending on the formulation requirements, dosage form, and manufacturing facility.
1. Pre-formulation: This step involves the selection of active pharmaceutical ingredients (APIs) and excipients, which are the inactive ingredients that help in the formulation and manufacturing of tablets. The compatibility of APIs and excipients is assessed, and their physical and chemical properties are evaluated.
2. Granulation: Granulation is the process of converting the powdered mixture of APIs and excipients into granules. This step improves the flowability, compressibility, and uniformity of the mixture. Granulation can be achieved through various methods such as wet granulation, dry granulation, or direct compression.
3. Blending: The granules are blended to ensure a homogeneous mixture. This step helps in achieving uniform distribution of APIs and excipients throughout the tablet.
4. Lubrication: Lubricants are added to the blended mixture to reduce friction between the tablet formulation and the tablet press. This step prevents sticking of the tablet to the punches and dies during compression.
5. Compression: The blended and lubricated mixture is compressed using a tablet press. The mixture is fed into the machine, and pressure is applied to form tablets of desired shape, size, and hardness.
6. Coating (optional): Tablets can be coated to improve their appearance, taste, and stability. Coating can also provide protection to the tablet from moisture, light, and other environmental factors. Coating can be done using various techniques such as sugar coating, film coating, or enteric coating.
7. Quality control: Throughout the formulation process, quality control tests are performed to ensure the tablets meet the required standards. These tests include weight variation, hardness, friability, disintegration, dissolution, and content uniformity.
8. Packaging: The final step involves packaging the tablets into suitable containers, such as blister packs or bottles, for distribution and storage.
It is important to note that the specific steps and techniques may vary depending on the formulation requirements, dosage form, and manufacturing facility.
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