Indications of classes of antiTB?

1. First-line drugs: These are the most commonly used drugs for treating TB and include isoniazid, rifampin, ethambutol, and pyrazinamide.

2. Second-line drugs: These drugs are used when first-line drugs are not effective or when the TB bacteria are resistant to them. Second-line drugs include fluoroquinolones, aminoglycosides, and other medications.

3. Combination therapy: TB is typically treated with a combination of drugs to prevent the development of drug resistance. This may involve using multiple first-line drugs or a combination of first-line and second-line drugs.

4. Directly Observed Therapy (DOT): This is a treatment strategy in which a healthcare provider or other trained individual directly observes the patient taking their medication to ensure adherence to the treatment regimen.

5. Drug-resistant TB treatment: For patients with drug-resistant TB, a combination of second-line drugs is used based on the specific resistance patterns of the TB bacteria. This may involve longer treatment durations and more frequent monitoring for side effects.

6. Latent TB infection treatment: For individuals with latent TB infection, treatment may involve a shorter course of isoniazid or a combination of isoniazid and rifapentine to prevent the development of active TB disease.

Class of AntiTB Agent | Indications
------- | --------
First-line:
- Isoniazid (INH) | Preferred regimen for all stages of TB
- Rifampin (RMP) | Essential for all regimens to treat active TB
- Ethambutol (EMB) | For regimens containing INH vs. RMP
- Pyrazinamide (PZA) | To shorten treatment regimens

Second-line:
- Fluoroquinolones (e.g., Levofloxacin, Moxifloxacin) | For drug-resistant TB or when first-line agents cannot be tolerated
- Aminoglycosides (e.g., Amikacin, Kanamycin) | For drug-resistant TB or when first-line agents cannot be tolerated
- Cycloserine | For drug-resistant TB
- Ethionamide | For drug-resistant TB
- Linezolid | For drug-resistant TB, especially with resistance to fluoroquinolones
- Pretomanid | For extensively drug-resistant (XDR) TB

Third-line:
- Para-aminosalicylic acid (PAS) | For drug-resistant TB or when first-line agents cannot be tolerated
- Capreomycin | For drug-resistant TB or when first-line agents cannot be tolerated

Additional Agents:
- Rifabutin | Alternative to RMP when RMP cannot be used
- Terizidone | Alternative to INH when INH cannot be used
- Clofazimine | For drug-resistant TB or atypical mycobacterial infections