Explosive substances are significant because they have the potential to cause significant damage, injury, and loss of life if not handled properly. They are used in various industries for mining, construction, and military purposes, but can also be used for malicious intent in acts of terrorism or violence. It is important to regulate and control the use of explosive substances to ensure the safety and security of individuals and communities. Additionally, research and development of explosive substances can lead to advancements in technology and innovation in various fields.