DNA appears as a long, double-stranded helical molecule that resembles a twisted ladder. The two strands of DNA are made up of nucleotides, which consist of a sugar-phosphate backbone and nitrogenous bases (adenine, thymine, cytosine, and guanine) that form hydrogen bonds with each other to hold the two strands together. The structure of DNA is often depicted as a double helix, with the nitrogenous bases on the inside of the helix and the sugar-phosphate backbone on the outside.