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What are the pharmacological effects of combined oral contraceptives?

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Combined oral contraceptives (COCs) contain synthetic versions of the hormones estrogen and progestin, which work together to prevent pregnancy by inhibiting ovulation, thickening cervical mucus to prevent sperm from reaching the egg, and thinning the lining of the uterus to prevent implantation of a fertilized egg.

In addition to their contraceptive effects, COCs have several other pharmacological effects on the body, including:

1. Regulation of menstrual cycles: COCs can help regulate menstrual cycles, making them more predictable and reducing symptoms of premenstrual syndrome (PMS).

2. Reduction of menstrual cramps: COCs can help reduce the severity of menstrual cramps by decreasing the amount of prostaglandins produced in the body.

3. Treatment of acne: COCs can help improve acne by reducing the production of sebum, a type of oil that can clog pores and lead to breakouts.

4. Reduction of menstrual bleeding: COCs can help reduce the amount and duration of menstrual bleeding, making periods lighter and shorter.

5. Protection against certain cancers: COCs have been shown to reduce the risk of developing ovarian and endometrial cancers.

6. Improvement of symptoms of polycystic ovary syndrome (PCOS): COCs can help regulate hormone levels in women with PCOS, improving symptoms such as irregular periods, acne, and excess hair growth.

It is important to note that COCs may also have potential side effects and risks, so it is important to discuss the benefits and risks with a healthcare provider before starting this form of contraception.
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