What are the differential diagnoses for a 55-year-old male with long-standing skin lesions for about 2 years, and the biopsy showed chronic granulomatous disease?

1. Cutaneous tuberculosis: Chronic granulomatous disease can present with skin lesions that resemble tuberculosis, so this should be considered as a differential diagnosis.

2. Sarcoidosis: Sarcoidosis is a systemic disease characterized by the formation of non-caseating granulomas in various organs, including the skin.

3. Fungal infections: Certain fungal infections, such as blastomycosis or histoplasmosis, can also present with chronic granulomatous skin lesions.

4. Foreign body granuloma: Chronic granulomatous disease can also be caused by a foreign body reaction to implanted materials, such as sutures or prosthetic devices.

5. Crohn's disease: Crohn's disease is a chronic inflammatory condition that can present with granulomatous skin lesions, known as metastatic Crohn's disease.

6. Leprosy: Leprosy is a chronic infectious disease caused by Mycobacterium leprae, which can present with granulomatous skin lesions.

7. Granuloma annulare: Granuloma annulare is a benign skin condition characterized by the formation of granulomatous lesions, typically on the hands and feet.

8. Rheumatoid nodules: Rheumatoid arthritis can present with subcutaneous nodules that resemble granulomas.

It is important for the patient to undergo further evaluation and testing to determine the underlying cause of the chronic granulomatous skin lesions and to initiate appropriate treatment.

- Sarcoidosis is a multisystem granulomatous disease that can affect the skin, lungs, lymph nodes, and other organs. It is characterized by the formation of noncaseating granulomas, which are collections of immune cells that form in response to an unknown trigger. Sarcoidosis can cause a variety of skin lesions, including erythema nodosum, lupus pernio, and plaques.
- Tuberculosis is a bacterial infection that can cause granulomatous inflammation in the skin and other organs. It is spread through the air and can be transmitted from person to person through close contact. Tuberculosis can cause a variety of skin lesions, including scrofuloderma, lupus vulgaris, and erythema induratum.
- Leprosy is a chronic bacterial infection that can cause granulomatous inflammation in the skin and other organs. It is spread through close contact with an infected person. Leprosy can cause a variety of skin lesions, including macular, papular, and nodular lesions.
- Fungal infections can also cause granulomatous inflammation in the skin. Examples include histoplasmosis, blastomycosis, and coccidioidomycosis. Fungal infections can be acquired through inhalation of spores or contact with contaminated soil or water.
- Other infections that can cause granulomatous inflammation in the skin include syphilis, cat scratch disease, and brucellosis.