1. Age: Rheumatic fever most commonly affects children between the ages of 5 and 15, although it can occur at any age.
2. Genetics: Individuals with a family history of rheumatic fever or autoimmune diseases may be at a higher risk of developing the condition.
3. Streptococcal infection: Rheumatic fever is often triggered by an untreated or inadequately treated streptococcal infection, such as strep throat or scarlet fever.
4. Socioeconomic factors: Individuals living in overcrowded or unsanitary conditions, with limited access to healthcare, may be at a higher risk of developing rheumatic fever.
5. Environmental factors: Exposure to environmental factors such as poor nutrition, lack of hygiene, and inadequate healthcare can increase the risk of developing rheumatic fever.
6. Immune system factors: Individuals with a weakened immune system or autoimmune disorders may be more susceptible to developing rheumatic fever.
7. Gender: Rheumatic fever is more common in females than males.
8. Race and ethnicity: Certain populations, such as Indigenous populations in Australia and New Zealand, have a higher prevalence of rheumatic fever.
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Google Gemini AI
Jul 31
Predisposing Factors:
- Presence of Group A Streptococcus (GAS) infection, particularly pharyngitis (strep throat)
Environmental Factors:
- Crowding and poor hygiene - Low socioeconomic status
Host Factors:
- Genetic susceptibility: Certain human leukocyte antigen (HLA) haplotypes, especially HLA-DR and HLA-DQ, are associated with an increased risk. - Age: Children and adolescents (5-19 years) are most commonly affected. - Race: Rheumatic fever is more prevalent in non-White populations. - Recent GAS infection: A history of scarlet fever or streptococcal pharyngitis within the past few weeks. - Autoimmunity: Individuals with a history of other autoimmune disorders (e.g., lupus erythematosus) may be more susceptible. - Immunodeficiency: Individuals with weakened immune systems may have an increased risk.
Other Associated Factors:
- Geographic location: Rheumatic fever is more common in developing countries. - Seasonality: Infections tend to occur more frequently during fall and winter months.