Outline major causes of generalized lymphadenopathy?

1. Infections: Viral, bacterial, fungal, and parasitic infections can cause generalized lymphadenopathy. Common infections include mononucleosis, HIV/AIDS, tuberculosis, and syphilis.

2. Autoimmune disorders: Conditions such as lupus, rheumatoid arthritis, and sarcoidosis can lead to generalized lymphadenopathy as the immune system mistakenly attacks healthy tissues.

3. Cancer: Lymphoma, leukemia, and metastatic cancer can cause enlarged lymph nodes throughout the body.

4. Medications: Certain medications, such as phenytoin, allopurinol, and penicillin, can trigger generalized lymphadenopathy as a side effect.

5. Immune system disorders: Disorders that affect the immune system, such as immunodeficiency syndromes, can result in generalized lymphadenopathy.

6. Systemic diseases: Conditions like sarcoidosis, Kawasaki disease, and Still's disease can cause generalized lymphadenopathy as part of their systemic effects.

7. Chronic inflammatory conditions: Chronic inflammatory conditions like inflammatory bowel disease and rheumatoid arthritis can lead to generalized lymphadenopathy.

8. Unknown causes: In some cases, the cause of generalized lymphadenopathy may be unknown, and further testing may be needed to determine the underlying cause.