Inherited antigenic substances, also known as inherited antigens or inherited determinants, are substances that are passed down from one generation to another through genetic inheritance. These substances can be proteins, carbohydrates, or other molecules that are recognized by the immune system as foreign and can elicit an immune response.
Inherited antigenic substances can be found on the surface of cells, such as red blood cells, or in body fluids, such as blood plasma. They play a crucial role in various biological processes, including tissue compatibility, immune response regulation, and disease susceptibility.
Examples of inherited antigenic substances include blood group antigens, human leukocyte antigens (HLAs), and major histocompatibility complex (MHC) molecules. These substances are highly polymorphic, meaning they exist in different forms or variants within a population. The diversity of inherited antigenic substances contributes to the individuality of immune responses and the ability to recognize and respond to a wide range of pathogens.
Inherited antigenic substances are important in transplantation medicine, as they determine the compatibility between the donor and recipient in organ or tissue transplantation. They are also relevant in blood transfusion, as mismatched blood group antigens can lead to adverse reactions.
Overall, inherited antigenic substances are essential components of the immune system and contribute to the body's ability to recognize and defend against foreign substances.