#drug choice for gonorrhea and their dose, dosage and course?

The recommended treatment for gonorrhea is a single dose of ceftriaxone 250 mg intramuscularly, along with azithromycin 1 g orally as a single dose. This dual therapy is recommended to ensure effective treatment and to help prevent the development of antibiotic resistance.

It is important to follow the prescribed dosage and course of treatment as directed by a healthcare provider. It is also important to abstain from sexual activity until the infection has been fully treated to prevent the spread of the infection to others.

Uncomplicated Gonorrhea

First-Line Treatment:

- Ceftriaxone:
- Dose: 125 mg IM as a single dose

Alternative Treatment Options:

- Cefixime:
- Dose: 400 mg orally as a single dose
- Ciprofloxacin:
- Dose: 500 mg orally as a single dose
- Note: Ciprofloxacin is no longer recommended as first-line therapy due to increasing antibiotic resistance.

Course:

- Treatment should be completed with a single dose of any of the recommended antibiotics.

Treatment of Gonorrhea with Concomitant Chlamydia:

- Azithromycin:
- Dose: 1 g orally as a single dose

Gonorrhea in Pregnancy:

- Ceftriaxone:
- Dose: 125 mg IM as a single dose

Gonorrhea in Infants and Children:

- Ceftriaxone:
- Dose: 50-100 mg/kg IM or IV once daily for 1-3 days

Gonorrhea in HIV-Infected Individuals:

- Ceftriaxone:
- Dose: 125 mg IM as a single dose
- Azithromycin:
- Dose: 1 g orally as a single dose

Treatment Failure:

- If treatment fails, testing for antibiotic resistance should be performed and alternative antibiotics should be considered.