Connexins are a family of proteins that form gap junction channels in cell membranes. These channels allow for the direct exchange of ions, small molecules, and signaling molecules between adjacent cells, enabling communication and coordination between cells in tissues and organs. Gap junctions formed by connexins play important roles in various physiological processes, including cell signaling, tissue development, and electrical conduction in the heart. Mutations in connexin genes have been linked to various diseases, including certain forms of deafness, skin disorders, and cardiac arrhythmias.