Cell Matrix adhesion?

Cell matrix adhesion refers to the interaction between cells and the extracellular matrix (ECM), which is a complex network of proteins and carbohydrates that surrounds cells and provides structural support. This adhesion is essential for cell survival, proliferation, differentiation, and migration.

Cells adhere to the ECM through specialized cell surface receptors called integrins, which bind to specific proteins in the ECM such as fibronectin, collagen, and laminin. This interaction triggers signaling pathways within the cell that regulate various cellular processes, including cell growth, gene expression, and cytoskeletal organization.

Disruption of cell matrix adhesion can lead to various cellular dysfunctions and diseases, including cancer, inflammation, and tissue fibrosis. Therefore, understanding the mechanisms of cell matrix adhesion is important for developing new therapeutic strategies for these conditions.