Rheumatic fever is caused by an untreated or inadequately treated streptococcal infection, specifically group A streptococcus. This bacterial infection usually starts as a strep throat or scarlet fever. If the infection is not properly treated with antibiotics, the bacteria can trigger an abnormal immune response in the body, leading to inflammation and damage to the heart, joints, skin, and brain.
Other factors that may increase the risk of developing rheumatic fever include:
1. Genetic predisposition: Some individuals may have a genetic susceptibility to developing rheumatic fever.
2. Environmental factors: Living in crowded or unsanitary conditions can increase the risk of exposure to streptococcal infections.
3. Age and gender: Rheumatic fever is more common in children between the ages of 5 and 15, and in females.
4. Socioeconomic factors: People living in low-income communities may have limited access to healthcare and may be at higher risk of developing rheumatic fever.
It is important to promptly treat streptococcal infections with antibiotics to prevent the development of rheumatic fever.
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Google Gemini AI
Jul 31
Infectious Agent
- Group A streptococcus (GAS) bacteria (specifically, strains carrying the M protein)
Mechanism
Rheumatic fever is an autoimmune condition triggered by a previous GAS infection, usually streptococcal pharyngitis (strep throat). After the initial infection, the body produces antibodies against the GAS bacteria. These antibodies can cross-react with proteins in the heart, joints, brain, and skin, leading to inflammation and damage.
Predisposing Factors
- Age: Children and adolescents are most commonly affected, typically between 5 and 15 years of age. - Genetics: Individuals with certain genetic predispositions may be more susceptible to developing rheumatic fever. - Environmental factors: Crowded living conditions and poor sanitation can increase the risk of GAS infections.
Risk Factors for Developing Rheumatic Fever After GAS Infection
- Not receiving appropriate antibiotic treatment for the initial GAS infection - Delays in seeking medical attention for a GAS infection - Previous episodes of rheumatic fever