Briefly explain how PTH brings about antagonistic or synergistic effect with any other hormone in regulating a given or particular metabolite?

Parathyroid hormone (PTH) can bring about antagonistic or synergistic effects with other hormones in regulating a particular metabolite, such as calcium.

In an antagonistic effect, PTH may oppose the actions of another hormone involved in calcium regulation. For example, calcitonin is a hormone that lowers blood calcium levels by inhibiting bone resorption. PTH, on the other hand, increases blood calcium levels by promoting bone resorption. Therefore, PTH and calcitonin have opposing effects on calcium regulation, creating an antagonistic relationship.

In a synergistic effect, PTH may work together with another hormone to enhance the regulation of a metabolite. For instance, PTH and vitamin D work synergistically to regulate calcium levels. PTH stimulates the production of active vitamin D (calcitriol) in the kidneys, which in turn enhances the absorption of calcium from the intestines. This collaboration between PTH and vitamin D results in a more efficient regulation of calcium levels.

Overall, PTH can interact with other hormones in both antagonistic and synergistic ways to regulate a specific metabolite, such as calcium. The specific nature of the interaction depends on the roles and mechanisms of the hormones involved.