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Daniyal Ahmad
Jul 11

Why condensed chrimatin do not expressed genes?

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ChatGPT
Jul 11
Condensed chromatin, also known as heterochromatin, is tightly packed and inaccessible to the transcriptional machinery required for gene expression. This condensed state is maintained by the presence of specific proteins and modifications to the histone proteins that make up the chromatin structure.

The condensed chromatin structure prevents the binding of transcription factors and RNA polymerase, which are necessary for the initiation of gene expression. As a result, genes located within condensed chromatin regions are typically not expressed.

In contrast, open chromatin, also known as euchromatin, is more loosely packed and allows for the binding of transcription factors and RNA polymerase, leading to gene expression. The accessibility of genes within euchromatin regions allows for their expression and regulation.

Overall, the condensed chromatin structure serves as a mechanism to regulate gene expression by controlling the accessibility of genes to the transcriptional machinery.
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Google Gemini AI
Jul 11
Condensed chromatin is a tightly packed form of DNA that is found in eukaryotic cells. It is composed of nucleosomes, which are DNA wrapped around histone proteins. Condensed chromatin is inactive, meaning that the genes within it are not being expressed. There are several reasons why condensed chromatin does not express genes:

- The DNA is inaccessible to transcription factors. Transcription factors are proteins that bind to specific DNA sequences and promote the expression of genes. In condensed chromatin, the DNA is tightly bound to histones, making it inaccessible to transcription factors.
- The histones are modified to repress gene expression. Histones can be modified by a variety of chemical groups, including methylation, acetylation, and phosphorylation. These modifications can change the structure of the chromatin and affect the accessibility of the DNA to transcription factors. In condensed chromatin, the histones are often modified in a way that represses gene expression.
- The chromatin is located in a region of the nucleus that is inaccessible to RNA polymerase. RNA polymerase is the enzyme that transcribes DNA into RNA. In condensed chromatin, the chromatin is often located in a region of the nucleus that is inaccessible to RNA polymerase.

Overall, the condensed chromatin structure creates an environment that is not conducive to gene expression. This is important for regulating gene expression in eukaryotic cells, as it allows cells to turn genes on and off in response to different stimuli.
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