What's the pathophysiology of non Hodgkin's lymphoma? ?

Non-Hodgkin's lymphoma is a type of cancer that originates in the lymphatic system, which is part of the body's immune system. The pathophysiology of non-Hodgkin's lymphoma involves the uncontrolled growth and proliferation of abnormal lymphocytes, which are a type of white blood cell that helps the body fight infections.

There are several subtypes of non-Hodgkin's lymphoma, each with its own unique pathophysiology. However, in general, the development of non-Hodgkin's lymphoma is thought to be caused by genetic mutations in the lymphocytes that disrupt the normal regulation of cell growth and division. These mutations can lead to the formation of tumors in the lymph nodes, spleen, bone marrow, or other organs of the lymphatic system.

The exact cause of these genetic mutations is not fully understood, but certain risk factors have been identified, including a weakened immune system, exposure to certain chemicals or radiation, and infections with certain viruses, such as the Epstein-Barr virus.

As the abnormal lymphocytes continue to grow and divide uncontrollably, they can crowd out normal cells in the lymphatic system, leading to the symptoms of non-Hodgkin's lymphoma, such as swollen lymph nodes, fever, night sweats, and weight loss. If left untreated, non-Hodgkin's lymphoma can spread to other parts of the body and become life-threatening.