Definition:
Antihypertensives, also known as blood pressure-lowering medications, are drugs used to treat high blood pressure (hypertension).
Mechanism of Action:
Different antihypertensives work through various mechanisms to reduce blood pressure, including:
- Diuretics: Increase urine output, reducing fluid volume in the blood.
- Beta-blockers: Block the sympathetic nervous system, decreasing heart rate and blood pressure.
- ACE inhibitors: Block the production of angiotensin II, a hormone that constricts blood vessels.
- ARBs (Angiotensin II Receptor Blockers): Block the effects of angiotensin II at receptors in blood vessels.
- Calcium channel blockers: Block the entry of calcium into cells, which can relax blood vessels.
- Vasodilators: Directly relax blood vessels, reducing resistance to blood flow.
Types of Antihypertensives:
There are numerous classes of antihypertensives, including:
- Diuretics (e.g., hydrochlorothiazide, spironolactone)
- Beta-blockers (e.g., metoprolol, atenolol)
- ACE inhibitors (e.g., lisinopril, enalapril)
- ARBs (e.g., losartan, valsartan)
- Calcium channel blockers (e.g., amlodipine, diltiazem)
- Vasodilators (e.g., hydralazine, minoxidil)
- Combination medications (e.g., Lisinopril/Hydrochlorothiazide, Amlodipine/Valsartan)
Indications:
Antihypertensives are prescribed to lower blood pressure and prevent the complications of high blood pressure, such as:
- Heart attack
- Stroke
- Kidney failure
- Heart failure
Dosage and Administration:
The dosage and administration of antihypertensives vary depending on the type of medication, the patient's individual needs, and the severity of hypertension.
Side Effects:
Common side effects of antihypertensives include:
- Dizziness
- Fatigue
- Headache
- Nausea
- Diarrhea
- Joint pain
Monitoring:
Regular monitoring of blood pressure and kidney function is essential while taking antihypertensives to ensure effectiveness and prevent side effects.