Types of muscle:- Ultrastructure, chemical composition, mechanism of contraction?
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Dec 10, 2023
There are three main types of muscle in the human body, each with distinct ultrastructure, chemical composition, and mechanism of contraction:
1. Skeletal Muscle: - Ultrastructure: Skeletal muscle is composed of long, cylindrical cells called muscle fibers. These fibers are multinucleated and have a striated appearance due to the arrangement of contractile proteins. - Chemical Composition: Skeletal muscle is primarily composed of contractile proteins called actin and myosin, along with other proteins such as troponin and tropomyosin that regulate muscle contraction. - Mechanism of Contraction: Skeletal muscle contraction is initiated by the release of calcium ions, which bind to troponin and cause a conformational change in the actin-myosin complex. This allows myosin heads to bind to actin, forming cross-bridges that generate force and cause muscle contraction.
2. Cardiac Muscle: - Ultrastructure: Cardiac muscle cells are branched and interconnected, forming a network of cells called cardiac tissue. They also have a striated appearance like skeletal muscle. - Chemical Composition: Cardiac muscle contains actin and myosin, similar to skeletal muscle. However, it also has specialized proteins called intercalated discs that allow for synchronized contraction of cardiac muscle cells. - Mechanism of Contraction: Cardiac muscle contraction is regulated by the influx of calcium ions, similar to skeletal muscle. However, the presence of intercalated discs allows for electrical signals to spread rapidly across cardiac tissue, coordinating the contraction of the heart.
3. Smooth Muscle: - Ultrastructure: Smooth muscle cells are spindle-shaped and lack striations. They are found in the walls of hollow organs such as the intestines, blood vessels, and uterus. - Chemical Composition: Smooth muscle contains actin and myosin, but in different proportions compared to skeletal and cardiac muscle. It also has additional proteins involved in regulating contraction, such as calmodulin. - Mechanism of Contraction: Smooth muscle contraction is initiated by the binding of calcium ions to calmodulin, which activates an enzyme called myosin light-chain kinase. This enzyme phosphorylates myosin, allowing it to bind to actin and generate force for contraction. Smooth muscle contractions are slower and more sustained compared to skeletal and cardiac muscle.