State food-drug interactions of progestin-only contraceptives.

Progestin-only contraceptives, such as the mini-pill or progestin-only implants, do not have any known food-drug interactions. However, it is important to take these contraceptives at the same time every day to ensure their effectiveness.

Decreased Effect of Progestin-Only Contraceptives by:

- CYP3A4 Inducers:
- Rifampin
- Carbamazepine
- Phenytoin
- Phenobarbital
- St. John's wort

- HIV protease inhibitors:
- Ritonavir
- Nelfinavir

- Hepatic enzyme inducers:
- Glutethimide
- Griseofulvin

Increased Effect of Progestin-Only Contraceptives by:

- CYP3A4 Inhibitors:
- Itraconazole
- Ketoconazole
- Fluconazole
- Clarithromycin
- Erythromycin

Other Effects:

- Calcium supplements: May reduce contraceptive efficacy
- Antacids: May interfere with absorption of oral progestin-only contraceptives