1. The O.J. Simpson murder case: Former NFL player O.J. Simpson was accused of murdering his ex-wife Nicole Brown Simpson and her friend Ron Goldman in 1994. The case gained widespread media attention and ultimately ended in Simpson's acquittal.
2. The JonBenét Ramsey murder case: In 1996, 6-year-old beauty queen JonBenét Ramsey was found murdered in her family's home in Boulder, Colorado. The case remains unsolved to this day and has sparked numerous theories and speculation.
3. The Zodiac Killer: The Zodiac Killer was a serial killer who operated in Northern California in the late 1960s and early 1970s. The killer taunted police and the media with cryptic letters and ciphers, and his identity remains unknown.
4. The Black Dahlia murder: In 1947, the body of aspiring actress Elizabeth Short, also known as the Black Dahlia, was found mutilated and cut in half in Los Angeles. The case remains one of the most famous unsolved murders in American history.
5. The disappearance of Madeleine McCann: In 2007, 3-year-old British girl Madeleine McCann disappeared from her family's holiday apartment in Portugal. The case received widespread media coverage and remains unsolved, with numerous theories and suspects being investigated.