Outline five systemic conditions that can manifest in the eye?

1. Uveitis: Uveitis is inflammation of the uvea, which is the middle layer of the eye. It can be a manifestation of various systemic conditions such as autoimmune diseases (e.g., rheumatoid arthritis, lupus), infections (e.g., tuberculosis, syphilis), or inflammatory bowel disease.

2. Diabetic retinopathy: Diabetic retinopathy is a complication of diabetes that affects the blood vessels in the retina. It occurs due to systemic changes in blood sugar levels and can lead to vision loss if left untreated.

3. Hypertensive retinopathy: Hypertensive retinopathy is a condition characterized by damage to the blood vessels in the retina due to high blood pressure. It can manifest as narrowing or blockage of blood vessels, hemorrhages, or swelling of the optic nerve.

4. Sarcoidosis: Sarcoidosis is a systemic inflammatory disease that can affect multiple organs, including the eyes. Ocular manifestations of sarcoidosis can include uveitis, granulomas in the conjunctiva or lacrimal glands, or optic nerve involvement.

5. Thyroid eye disease: Thyroid eye disease, also known as Graves' ophthalmopathy, is an autoimmune condition associated with an overactive thyroid gland. It can cause inflammation and swelling of the tissues around the eyes, leading to symptoms such as bulging eyes, double vision, or dryness.