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Nov 13, 2023

Outline causes of splenomegaly?

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Nov 13, 2023
I. Introduction to splenomegaly
A. Definition of splenomegaly
B. Importance of the spleen in the body

II. Infectious causes of splenomegaly
A. Bacterial infections
1. Bacterial endocarditis
2. Tuberculosis
3. Brucellosis
B. Viral infections
1. Infectious mononucleosis
2. Cytomegalovirus (CMV) infection
3. Hepatitis
C. Parasitic infections
1. Malaria
2. Leishmaniasis
3. Schistosomiasis

III. Hematological causes of splenomegaly
A. Hemolytic anemias
1. Sickle cell disease
2. Thalassemia
3. Autoimmune hemolytic anemia
B. Myeloproliferative disorders
1. Chronic myeloid leukemia (CML)
2. Polycythemia vera
3. Essential thrombocythemia
C. Lymphoproliferative disorders
1. Hodgkin's lymphoma
2. Non-Hodgkin's lymphoma
3. Chronic lymphocytic leukemia (CLL)

IV. Inflammatory causes of splenomegaly
A. Rheumatological diseases
1. Systemic lupus erythematosus (SLE)
2. Rheumatoid arthritis
3. Sarcoidosis
B. Inflammatory bowel disease
1. Crohn's disease
2. Ulcerative colitis
C. Vasculitis
1. Polyarteritis nodosa
2. Giant cell arteritis

V. Metabolic causes of splenomegaly
A. Gaucher's disease
B. Niemann-Pick disease
C. Amyloidosis

VI. Other causes of splenomegaly
A. Congestive splenomegaly
B. Splenic vein thrombosis
C. Splenic cysts or tumors

VII. Conclusion
A. Summary of causes of splenomegaly
B. Importance of identifying the underlying cause for appropriate management.
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