High dietary methionine supply is associated with a decrease in the availability of substrates for remethylation.

This can lead to a decrease in the production of S-adenosylmethionine (SAMe), which is an important methyl donor in various biochemical reactions in the body. This can have negative effects on processes such as DNA methylation, neurotransmitter synthesis, and detoxification pathways. Additionally, high methionine intake has been linked to an increased risk of cardiovascular disease, liver damage, and certain types of cancer. Therefore, it is important to maintain a balanced intake of methionine in the diet to support optimal health and biochemical function.

Correct