Anonymous
Jan 8
Gene therapies ex vivo and invo therapy? Antigens therapy and antisense therapy?
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Jan 8
Gene therapies can be classified into two main categories: ex vivo therapy and in vivo therapy.
Ex vivo therapy involves the removal of cells from the patient's body, modification of the cells in the laboratory, and then reintroduction of the modified cells back into the patient. This approach is commonly used in the treatment of certain types of cancer, where immune cells are extracted, genetically modified to enhance their anti-tumor activity, and then infused back into the patient.
In contrast, in vivo therapy involves the direct delivery of therapeutic genes into the patient's body, typically using viral vectors or non-viral methods. This approach is used to target specific tissues or organs and is being explored for the treatment of various genetic disorders, such as muscular dystrophy and hemophilia.
Antigens therapy refers to a type of gene therapy that aims to stimulate the immune system to recognize and attack specific antigens, such as cancer cells. This can be achieved by introducing genes encoding tumor-specific antigens into the patient's cells, which then trigger an immune response against the cancer cells.
Antisense therapy, on the other hand, involves the use of synthetic nucleic acids (antisense oligonucleotides) to target and inhibit the expression of specific genes. These oligonucleotides bind to the messenger RNA (mRNA) molecules that carry the genetic instructions for protein synthesis, preventing their translation into proteins. Antisense therapy has shown promise in the treatment of genetic disorders caused by the abnormal expression of specific genes, such as spinal muscular atrophy and Duchenne muscular dystrophy.
Ex vivo therapy involves the removal of cells from the patient's body, modification of the cells in the laboratory, and then reintroduction of the modified cells back into the patient. This approach is commonly used in the treatment of certain types of cancer, where immune cells are extracted, genetically modified to enhance their anti-tumor activity, and then infused back into the patient.
In contrast, in vivo therapy involves the direct delivery of therapeutic genes into the patient's body, typically using viral vectors or non-viral methods. This approach is used to target specific tissues or organs and is being explored for the treatment of various genetic disorders, such as muscular dystrophy and hemophilia.
Antigens therapy refers to a type of gene therapy that aims to stimulate the immune system to recognize and attack specific antigens, such as cancer cells. This can be achieved by introducing genes encoding tumor-specific antigens into the patient's cells, which then trigger an immune response against the cancer cells.
Antisense therapy, on the other hand, involves the use of synthetic nucleic acids (antisense oligonucleotides) to target and inhibit the expression of specific genes. These oligonucleotides bind to the messenger RNA (mRNA) molecules that carry the genetic instructions for protein synthesis, preventing their translation into proteins. Antisense therapy has shown promise in the treatment of genetic disorders caused by the abnormal expression of specific genes, such as spinal muscular atrophy and Duchenne muscular dystrophy.
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