Describe the mechanism of poisoning by hazardous substances and provide references.
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Oct 21
Poisoning by hazardous substances occurs when toxic chemicals or materials are ingested, inhaled, or come into contact with the skin or eyes, leading to harmful effects on the body. The mechanism of poisoning can vary depending on the specific substance involved, but generally involves the following steps:
1. Absorption: The hazardous substance enters the body through ingestion, inhalation, or skin contact.
2. Distribution: The substance is distributed throughout the body via the bloodstream, reaching various organs and tissues.
3. Metabolism: The substance may undergo chemical reactions in the body, leading to the formation of toxic metabolites.
4. Target organ effects: The toxic substance exerts its harmful effects on specific organs or systems in the body, disrupting normal physiological functions.
5. Cellular damage: The substance may cause damage to cells, tissues, and organs, leading to symptoms of poisoning such as nausea, vomiting, dizziness, respiratory distress, or organ failure.
6. Elimination: The body attempts to eliminate the toxic substance through processes such as metabolism, excretion, or detoxification.
It is important to seek immediate medical attention if poisoning is suspected, as prompt treatment can help prevent serious complications or death. Additionally, proper handling and storage of hazardous substances, as well as following safety guidelines and using personal protective equipment, can help prevent accidental poisoning.
References:
1. Agency for Toxic Substances and Disease Registry (ATSDR). (2015). Principles of Toxicology. Retrieved from: https://www.atsdr.cdc.gov/toxprofiles/tp200-c1.pdf
2. National Institute of Environmental Health Sciences (NIEHS). (2021). Poisoning. Retrieved from: https://www.niehs.nih.gov/health/topics/agents/poisons/index.cfm
3. World Health Organization (WHO). (2010). Principles for evaluating health risks in children associated with exposure to chemicals. Retrieved from: https://www.who.int/ceh/publications/children/en/