> #superovulation , #procedure-of-ivf , #collection , #cryopreservation-of-gametes , #in-vitro-maturation , #causes-of-infertility-in-humans , #screening-of-genetic-disorder , #in-vitro-fertilization > Causes of infertility in humans?, In vitro fertilization:- superovulation, collection and cryopreservation of gametes in vitro maturation, screening of genetic disorder, procedure of IVF?
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Jan 7

Causes of infertility in humans?, In vitro fertilization:- superovulation, collection and cryopreservation of gametes in vitro maturation, screening of genetic disorder, procedure of IVF?

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Jan 7
Causes of infertility in humans can vary and may include:

1. Ovulation disorders: Problems with ovulation, such as polycystic ovary syndrome (PCOS) or hormonal imbalances, can lead to infertility.

2. Fallopian tube damage or blockage: Conditions like pelvic inflammatory disease (PID), endometriosis, or previous surgeries can cause damage or blockage in the fallopian tubes, preventing the sperm from reaching the egg.

3. Uterine or cervical abnormalities: Abnormalities in the uterus or cervix, such as fibroids, polyps, or cervical stenosis, can interfere with the implantation of a fertilized egg.

4. Male factor infertility: Issues with sperm production, quality, or delivery can contribute to infertility. These may include low sperm count, poor motility, or structural abnormalities.

5. Age-related infertility: As women age, their fertility declines due to a decrease in the number and quality of eggs.

In vitro fertilization (IVF) is a fertility treatment that involves several steps:

1. Superovulation: The woman is given fertility medications to stimulate the ovaries to produce multiple eggs instead of the usual one egg per cycle.

2. Collection and cryopreservation of gametes: The eggs are retrieved from the woman's ovaries using a minor surgical procedure called follicular aspiration. The sperm sample is collected from the male partner or a donor. Both the eggs and sperm can be cryopreserved (frozen) for future use if needed.

3. In vitro maturation (optional): In some cases, immature eggs can be collected and matured in the laboratory before fertilization.

4. Fertilization: The eggs and sperm are combined in a laboratory dish, and fertilization occurs. This can be done through conventional IVF, where the sperm is added to the dish containing the eggs, or through intracytoplasmic sperm injection (ICSI), where a single sperm is directly injected into each egg.

5. Screening of genetic disorders (optional): Preimplantation genetic testing (PGT) can be performed on the embryos to screen for specific genetic disorders or chromosomal abnormalities before they are transferred to the uterus.

6. Embryo transfer: The resulting embryos are transferred into the woman's uterus using a thin catheter. This is typically a painless procedure.

7. Follow-up: After the embryo transfer, the woman may be prescribed medications to support implantation and pregnancy. A pregnancy test is usually done about two weeks after the embryo transfer to determine if the IVF cycle was successful.
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