The first line of defense in the human body is the innate immune system, which acts as a barrier to prevent pathogens from entering the body. This includes physical barriers such as the skin and mucous membranes, as well as chemical barriers such as stomach acid and enzymes in tears and saliva. These barriers work together to prevent pathogens from entering the body and causing infection. If a pathogen does manage to breach these barriers, the innate immune system also includes cells such as macrophages and neutrophils that can quickly respond to and eliminate the threat. Overall, the first line of defense is crucial in protecting the body from harmful pathogens and maintaining overall health.